In Cañon Creek, Frank Shasta finds a dead cow on Glen Hocking’s range. After an examination, the veterinarian, Doc Lowe, concludes that it died of anthrax and all of Hocking’s infected cattle will need to be destroyed. Hocking refuses, insisting it is a scheme on Doc Lowe’s part to make money. The Feud begins when Guy Dymond caught Galt Majors in bed with his wife. Guy shot Galt but didn’t kill him. Since then, Galt has become wealthy while Guy has lived in poverty. When Galt’s son gets Guy’s daughter Lena pregnant, Guy and his four sons make a daring raid on the Majors ranch.